| Blue Cast | Purple Cast | |
| Gannon Stearns | Damian | Gates Smyth |
| Jenna Claywell | Janis Sarkisian | Lee Barber |
| Paige Adkins | Cady Heron | Josi Anderson |
| Kara Peters | Ms. Norbury | Jasmine Sexton |
| Reagan Lueker | Regina George | Sydney Hall |
| Addyson Fischer | Gretchen Wieners | Emma Hatcher |
| Alina Fanshier | Karen Smith | Jade Brewer |
| Zach Perkins | Aaron Samuels | Dylan Maynard |
| Tori Akin | Mrs. Heron/Caroline Krafft | Alisia Marcum |
| Ethan Amburgey | Mr. Duvall | Pierce Barron |
| Braydon Ward | Shane Oman | Callum Bailey |
| Kai Kukas | Kevin G | Theo McPherson |
| Talon Barnes | Martin | Charity Blanton |
| Sydney Ray | Mrs. George | Kate Patrick |
| Kennedy Lueker | Mr. Heron/Moderator | Jace Stanley |
| Emma Schat | French Teacher/Sophie/Marymount 1 | Jenna Fair |
| Summer Grazinno | Coach Carr/Marymount Capt | Kenedee Fair |
| Kaylee Neal | Taylor/Dawn/Marymount 2 | Emma Price |
| Savanna Burton | Catilyn/Grace/Marymount 3 | Avery Boggs |
| Emily Ritchie | Rachel/LIzzie | Anaeity McPherson |
| Adalynn Coleman | Sonja/Teary Girl | Paelyn Miller |
| Glenn/Tony | Oliver Miller |